Industrial Lyophilizer
(a)10 series
Lab Scales Desktop(Freeze-dried material 1.5-2KG)
(b)12 series
Lab Scales Vertical(Freeze-dried material 2KG)
(c)18 series
Scientific Research Scales(Freeze-dried material 3KG)
2.Pilot Freeze Dryer:
0.2m²/0.3m²/0.5m²/1m²/2m²/---Pilot Scales(Freeze-dried material 3KG-20KG)
3.Industrial Freeze Dryer:
5㎡/10㎡/20㎡/30㎡/50㎡/100㎡/200㎡/300㎡(Freeze-dried Weight 5T~60T)
4.Customization: set up the specifications you need
(a)Freeze-dried Area
(b)Freeze-dried Weight
(c)Freeze-dried Material
(d)Interlayer Quantity/Size
(e)Cold Trap Temperature
Description
Technical Parameters
An Industrial Lyophilizer,is a specialized piece of equipment utilized for the removal of water from a material through a process known as freeze drying or lyophilization.This technology,originating in the 1920s,has evolved over the years and is now widely applied across various industries due to its unique advantages.
It typically consists of several key components: a drying chamber,a condenser,a refrigeration unit,a vacuum system,and a heating/cooling system.The material to be dried is first loaded into the drying chamber and frozen to the desired temperature.The vacuum system then creates a low-pressure environment within the chamber,allowing the sublimation process to occur.The heat provided by the heating system supplies the latent heat of sublimation required for the ice to transition to vapor.The condenser captures and condenses the water vapor,releasing the latent heat of condensation.The refrigeration unit cools the condenser to maintain the low temperature necessary for condensation.
(View other types: Laboratory;Pilot;Industrial)
Specifications Chart
Operational Process
Pre-Operation Preparation:
- Ensure it is in a clean and sterile environment to prevent contamination of the material.
- Check the power supply and ensure all electrical connections are secure.
- Verify that the refrigerant supply and coolant levels are sufficient.
- Ensure the vacuum pump is in working order and has an adequate oil level.
Loading the Material:
- Prepare the material to be freeze-dried according to the specific requirements of the process.
- Load the material into the its chamber,ensuring it is evenly distributed and not overcrowded.
- Close the chamber door securely.
Setting the Operating Parameters:
- Adjust the its control panel to set the desired freeze-drying parameters.
- Set the initial freezing temperature to quickly and evenly freeze the material.
- Adjust the vacuum level based on the material's properties and the desired drying rate.
- Set the duration of the primary drying phase,which involves sublimation of ice from the material.
- If necessary,set the parameters for the secondary drying phase,which removes residual moisture bound to the material.
Starting the Freeze-Drying Process:
- Initiate the freeze-drying cycle by starting the vacuum pump and the refrigeration system.
- Monitor the temperature,vacuum level,and other critical parameters throughout the process.
- Adjust the parameters if necessary to maintain optimal drying conditions.
Post-Drying Operations:
- Once the freeze-drying cycle is complete,gradually increase the chamber pressure to avoid damaging the material.
- Open the chamber door and carefully remove the dried material.
- Clean and sanitize the chamber and components to prepare for the next cycle.
Maintenance and Inspection:
- Regularly inspect the components,including the vacuum pump,refrigeration system,and heating elements,for wear and tear.
- Replace worn-out parts promptly to ensure the optimal performance.
- Clean and sanitize the entire system periodically to maintain hygiene and prevent contamination.
Application in Cosmetics
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Concept and preparation principle of freeze-dried powder
Lyophilized powder is usually frozen into a solid state at a lower temperature(-10℃~-50℃)in a sterile environment,and then sublimates the water directly into a gaseous state under vacuum conditions(1.3Pa~13Pa)without passing through the liquid state.,thereby drying the prepared solid powder.This solid powder mainly consists of basic substances such as excipients and protective agents,such as mannitol,while the active substances that actually exert the effect are evenly distributed in the skeleton structure.
The preparation method of freeze-dried powder is freeze-drying technology,that is,vacuum freeze-drying technology.The English name is Freeze-Dried,so it is also called FD technology.It is a drying method that uses the principle of sublimation to dehydrate materials at low temperature.For most chemical and biological products,water acts as a solvent.However,water is also a major cause of product spoilage during storage.Therefore,the preservation of unstable products can be achieved by reducing the moisture content,thereby appropriately extending the storage time and facilitating product transportation.For freeze-drying technology,the final moisture content of the product is closely related to the shelf life of the product.Therefore,water content is one of the key assessment indicators for the quality of freeze-dried products.
Advantages
Today,consumers are paying more and more attention to the ingredients in cosmetic formulas and their efficacy.However,highly active ingredients are usually physically and chemically unstable,especially under normal and liquid conditions,and can easily lose or weaken their activity.Since vacuum freeze-drying technology is carried out in a low-temperature,low-oxygen environment,most biological reactions are stagnant,and there is no liquid water in the treatment process.The water directly sublimates in a solid state,causing less damage to the structure and characteristics of tissues and cells,so the material The original structure and shape of the product are protected to the greatest extent.At the same time,the freeze-drying technology effectively retains the original characteristics of the ingredients,especially improves the stability of many heat-sensitive active ingredients,and protects and retains some highly bioactive or easily oxidized ingredients.activity,and finally obtain high-quality dry products with both appearance and intrinsic quality.The color of freeze-dried powder products basically does not change after drying,and the morphological structure is relatively loose.After adding solvents such as water,it can quickly dissolve and return to solution form,showing its original physical and chemical properties and biological activity.In addition,in view of the preparation principle of freeze-dried powder,the moisture content in freeze-dried powder is very low,which greatly improves the stability of the product,which not only facilitates transportation but also extends the shelf life of the product.
Compared with the traditional cosmetic preparation process,the preparation process of freeze-dried powder is carried out under sterile conditions,and no preservatives are added,and preservatives are the main ingredients that cause irritation to the skin,so it is helpful to reduce the use of the possibility of skin allergies.At the same time,in the freeze-dried powder state,bacteria and viruses cannot survive and reproduce due to lack of water,which effectively prevents the product from being contaminated and can also help extend the storage time of the product and its active ingredients.
Application in cosmetics
Freeze-drying technology was first used during World War II.A large amount of human plasma was needed to rescue the wounded.The blood was made into powder for easy storage and transportation.When used,the sterile products were compounded back into the plasma,which largely satisfied the demand for blood products..Traditional freeze-drying technology is widely used in the military,aerospace,biomedical and food fields.With the rapid development of freeze-drying technology,in recent years,freeze-dried powder-type preparation products have begun to enter the cosmetics industry.
At present,the most common active ingredients in cosmetic freeze-dried powder preparations are proteins(such as collagen,placental protein,etc.),peptides(such as oligopeptide-1,tripeptide-1 copper,etc.)and vitamins(such as vitamin C,etc.).What these ingredients have in common is that their physical and chemical properties are extremely unstable under normal temperature or liquid conditions.Protein and peptide ingredients are usually heat-sensitive and are easily weakened or lose their activity.Vitamin C and other ingredients are prone to oxidation reactions and thus lose their antioxidant capacity.Preparing these "fragile" functional ingredients into freeze-dried powder preparations can effectively improve product stability,so that after going through production,transportation,storage and other links,they can still play their due role when consumers use them.The efficacy of freeze-dried powder cosmetics depends on the active ingredients contained.The specific functions include skin barrier soothing and repair,skin color brightening,fine lines reduction,antioxidant,acne removal,etc.
Promote milk powder production
Industrial freeze-dryers are carried out in low temperatures(usually below 50°C)and oxygen-poor vacuum environments throughout the processing process.This environment ensures that the nutrients in the milk powder,especially those heat sensitive active substances such as immunoglobulins,vitamins,minerals and EGF(epidermal growth factor),are effectively retained.These ingredients are essential for the healthy growth of infants and young children,and the traditional spray drying process often leads to a large loss of these nutrients due to high temperature treatment.
The natural flavor,quality and color of milk powder treated by freeze-drying technology can remain unchanged.This is because the freeze-drying process avoids the damage of high temperature and strong oxidation environment to the milk powder,thus maintaining the original physical structure and molecular structure of the milk powder.This high-quality milk powder not only tastes better,but also is easier for infants to digest and absorb.
Industrial freeze-dryer adopts advanced automatic control system,which can monitor and adjust various parameters in the drying process in real time,such as temperature,pressure,humidity and so on.This precise control not only ensures the stability and consistency of the drying process,but also greatly improves production efficiency.At the same time,because the freeze-drying technology can remove most of the water in the milk powder,the dried milk powder is smaller and lighter,which is easy to store and transport.
By removing most of the moisture in milk powder,industrial freeze dryers significantly extend the shelf life of milk powder.This is because moisture is one of the necessary conditions for microbial growth and reproduction,and freeze-drying technology reduces the moisture content in milk powder to extremely low levels,thus inhibiting the growth of bacteria and mold.This long-life milk powder is not only more suitable for long-distance transportation and storage,but also reduces waste caused by deterioration.
Because industrial freeze dryers have many of the above advantages in the production of milk powder,milk powder produced using this technology has a higher competitiveness in the market.These benefits include better product quality,longer shelf life,higher nutritional value and better taste.These characteristics make consumers more willing to choose the milk powder produced by freeze-drying technology,thus promoting the healthy development of the milk powder market.
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