Lyophilization Machine
(a)10 series
Lab Scales Desktop(Freeze-dried material 1.5-2KG)
(b)12 series
Lab Scales Vertical(Freeze-dried material 2KG)
(c)18 series
Scientific Research Scales(Freeze-dried material 3KG)
2.Pilot Freeze Dryer:
0.2m²/0.3m²/0.5m²/1m²/2m²/---Pilot Scales(Freeze-dried material 3KG-20KG)
3.Industrial Freeze Dryer:
5㎡/10㎡/20㎡/30㎡/50㎡/100㎡/200㎡/300㎡(Freeze-dried Weight 5T~60T)
4.Customization: set up the specifications you need
(a)Freeze-dried Area
(b)Freeze-dried Weight
(c)Freeze-dried Material
(d)Interlayer Quantity/Size
(e)Cold Trap Temperature
Description
Technical Parameters
Lyophilization machine,also known as freeze dryer,is a device that removes water from substances through a process called freeze-drying.This process involves freezing the material first,followed by the application of vacuum and heat to sublime the ice directly from solid to vapor,bypassing the liquid state.Freeze drying is often used in preserving biological samples,pharmaceuticals,and foods,as it can maintain the structure and activity of the material better than other drying methods.The freeze dryer typically consists of a refrigeration system for freezing,a vacuum pump for creating a low-pressure environment,and heating elements for sublimation.This combination allows for gentle and efficient water removal,resulting in a high-quality,long-lasting dried product.Choosing a manufacturer with good after-sales service and technical support can ensure the normal operation and maintenance of the equipment. In the choice, you can pay attention to the reputation of the manufacturer, after-sales service policy and user evaluation and other information.
Specifications Guide
10 Series
12 Series
18 Series
Heating Methods
Electric Heating
Silicone Oil Heating
Classifications
Lyophilization machines are classified into various types based on their specific applications,working principles,and structural designs.
Based on Applications
Laboratory Freeze Dryers
These are primarily used in research settings such as biopharmaceuticals,food processing,and other industrial fields.They are employed for tasks like concentrating bacteria,extracting proteins,and preparing viral products.These machines typically consist of a vacuum system,refrigeration system,temperature control system,and safety features.
Industrial Freeze Dryers
Designed for large-scale production,they are used in the dehydration of chemicals,pharmaceutical ingredients,and various materials,including liquids,gases,and solid particles.They are efficient and energy-saving,especially suitable for dehydrating heat-sensitive substances in the chemical industry.
Food-Grade Freeze Dryers
These are specifically used in food processing,particularly for the production of fruit and vegetable chips,canned foods,and meat products.Their reliability and ease of use make them a popular choice in the meat processing industry.
Based on Working Principles and Methods
Chamber-Type Freeze Dryers
These high-end laboratory devices feature a sealed chamber with excellent airtightness.They include a vacuum system,control system,and other accessories,capable of drying various gas,liquid,and solid samples uniformly.
Tube-and-Shell Freeze Dryers
Composed of isolated thin tubes,high-pressure pumps,temperature controllers,vacuum suppliers,and dehydrators,they are designed for efficient heat transfer and drying.
Drum-Type Freeze Dryers
Utilizing stacked cylindrical containers with heat transfer systems and control devices,they are compact,easy to operate,and suitable for freezing and drying both inorganic and organic materials.
Based on Structural Designs
Shelf-Type Freeze Dryers
Commonly used for foods,herbs,and powders,they have shelves where materials are placed for drying.
In-situ Freeze Dryers
These feature separate drying chambers and condensing chambers.The shelves within the drying chamber have cooling capabilities,eliminating the need for manual handling during the pre-freezing and drying processes.While expensive to manufacture,they are ideal for exploring freeze-drying processes,especially in the pharmaceutical and biological product industries.
Bell-Jar Freeze Dryers
With separate drying and condensing chambers,they lack pre-freezing capabilities within the drying chamber.Many experimental freeze dryers adopt this design due to its simplicity and low cost.
Additionally,they can also be classified based on the type of refrigerant used(e.g.,fluorocarbon or ammonia compressor systems),the automation level(fully automatic or semi-automatic),the refrigerant system design(plate heat exchanger or non-plate type),and the intended usage scenarios(general or specialized applications).
In summary,Lyophilization machines are diverse in their applications,working principles,and structural designs.Understanding these classifications is crucial for selecting the appropriate freeze dryer for specific needs in various industries.
The pre-freezing time of the freeze-dryer
Understand material characteristics
Material type:Different types of materials have different moisture content,crystallization point and thermal sensitivity,which will affect the choice of pre-freezing time.For example,the moisture content of vegetables and fruits is moderate and easy to sublimate,and the pre-freezing time may be relatively short;Biological products such as vaccines,enzymes,etc.,may require longer pre-freezing time due to their complex composition and sensitivity to temperature.
Material thickness:The thickness of the material will affect the rate of heat and mass transfer,thus affecting the pre-freezing time.Generally speaking,the thinner material freeze-drying speed is faster,and the pre-freezing time is relatively short;Thicker materials may require a longer pre-freezing time to ensure that the internal moisture is completely frozen.
Set the pre-freezing temperature
The pre-freezing temperature should usually be 5~10℃ lower than the eutectic point temperature of the material to ensure that the water in the material can be completely frozen.The eutectic point is the temperature point at which all components of a material crystallize simultaneously.The eutectic point temperature of the material can be determined and the pre-freezing temperature can be set according to the relevant literature or experiments.
Pre-experiment
Set different pre-freezing time:under the same pre-freezing temperature,set several different combinations of pre-freezing time for experiment.
Observation of freeze-drying effect:After the end of pre-freezing,sublimation drying and analytical drying were carried out,and the appearance,quality and yield of freeze-dried products were observed.
Determine the best pre-freezing time:According to the experimental results,select the best freeze-drying effect of the pre-freezing time as the final parameter.
Consider the performance of the freeze-drying machine
The performance of the freeze-drying machine will also affect the determination of the pre-freezing time.For example,high-power,high-efficiency freeze-drying machines can lower temperatures faster and meet pre-freezing requirements,thereby reducing pre-freezing time.Therefore,in the choice of freeze-drying machine,should understand its performance and characteristics,in order to more accurately determine the pre-freezing time.
Record and adjust
After determining the pre-freezing time,it should be recorded and verified and adjusted in the subsequent production process.If it is found that the freeze-drying effect is not ideal or the material characteristics change,the pre-freezing time should be adjusted in time to ensure the best freeze-drying effect.
Applications
Freeze-dried coffee
Freeze-dried coffee tablets better retain the original flavor of coffee.Due to their loose and porous internal structure,they dissolve quickly.They are"instant coffee"that is easy to measure and the concentration of the resulting beverage can be easily controlled.The optimized preparation process conditions are:extraction temperature 90°C,extraction time 12 minutes,material-liquid ratio 1:15,extract liquid concentrated to 65% concentration,packaged and placed in a freeze dryer below -36°C.Vacuum dry for more than 20h.The prepared freeze-dried tablets have a smooth surface,complete tablet shape,and pure flavor.They are convenient for drinking at home,traveling,in offices,and for people who have difficulty getting hot water,and have broad market prospects.
The Difference Between Freeze-dried Coffee & Instant Coffee
Craftsmanship
Freeze-drying coffee is to quickly freeze fresh coffee liquid,and use the principle of sublimation to sublimate the water under low temperature conditions to obtain dry coffee powder.Instant coffee is a powder obtained by removing the water from the coffee liquid through spray drying or freeze drying.
Taste and nutritional content
Compared with instant coffee,freeze-dried coffee has a richer taste and longer-lasting aroma.This is because during the sublimation process,freeze-dried coffee can better retain the original flavor and nutrients in the coffee beans.Instant coffee,on the other hand,may lose some nutrients during the production process,so its taste is relatively light.
Brewing method
Freeze-dried coffee usually requires hot water to brew,and it needs to be stirred evenly to ensure that the coffee powder is fully dissolved.It has a pure flavor and provides convenience for drinking at home,traveling,in the office and for those who have difficulty getting hot water,and has broad market prospects.Instant coffee can be added directly to hot water and dissolves quickly without stirring.In addition,instant coffee can also be added to cold water or milk to make drinks such as latte,which is more convenient to use.
To sum up,freeze-dried coffee and instant coffee each have their own advantages and disadvantages.If you are looking for rich taste and nutritional value,you can choose freeze-dried coffee;if you need a convenient and fast drink,you can choose instant coffee.
Our company's Lyophilization machines offer significant advantages in the production of freeze-dried coffee.Firstly,our machines utilize advanced freeze-drying technology,ensuring that the coffee beans retain their original flavor,aroma,and nutritional value during the drying process.This results in a coffee product that tastes fresh and delicious,even after long-term storage.Secondly,our freeze dryers are designed with energy efficiency as a top priority,reducing operational costs and environmental impact.Additionally,our machines feature user-friendly controls and robust construction,making them easy to operate and maintain.Finally,we pride ourselves on our commitment to quality and innovation,ensuring that our customers receive the best possible freeze-dried coffee products.In summary,our freeze dryers offer a superior solution for producing high-quality freeze-dried coffee that meets the demands of today's market.
Applicable materials
Food processing field
Fruit: Lychee, longan, banana, strawberry, peach, cherry, apple, pear, orange, cantaloupe, pineapple, mango, avocado, FIG, lemon, durian, raspberry, blueberry, etc.
Vegetables: Mushrooms, shiitake mushrooms, asparagus, celery, green beans, Dutch beans, peas, carrots, tomatoes, cabbage, spinach, onion, corn, coriander, chives, seeds, yam, purple potato, onion, garlic, etc.
Aquatic products: shrimp, crab meat, turtle, jellyfish, squid, sea cucumber, abalone, shellfish, fish, scallop, kelp, etc.
Poultry: duck, beef, mutton, chicken, pork, rabbit, ham, barbecued meat, egg products, prawns, etc.
Convenience food: boxed meals, baby food, elderly food, military food, aerospace food, instant noodles, convenient porridge, pet food, etc.
Drinks: instant coffee, instant tea and other solid drinks, fruit juice, fruit tea, vegetable juice, nutritional powder, red green tea, etc.
Seasonings: onion, ginger, garlic, soup (such as vegetable egg soup, tomato soup, seafood soup), jam, condiments, spices, etc.
The field of medicine and health products
Chinese medicinal materials and health tonic
ginseng, deer antler, Cordyceps, Gastrodia, Angelica, Notoginseng, bird's nest, Polygonum multiflorum, yam, Dendrobium officinale, forest frog oil, wolfberry, First aconite, royal jelly, honey, deer products, bovine colostrum, placenta, etc.
Biological products and drugs
biological agents, medicinal raw materials, nutritional solutions, reagents, plasma, snake venom, bear bile, anthocyanins, ginkgo biloba, fungi, enzymes, antibiotics, penicillin, serum, pollen, Chinese herbal medicine, etc.
Chemical raw materials field
Dyes and pigments
Dyes and pigments are easy to absorb moisture during production and storage, resulting in a decline in product quality. The freeze-drying machine can remove the moisture in dyes and pigments through low temperature freezing and vacuum drying to maintain its bright color and stability.
Pesticides and pesticide intermediates
It is also necessary to avoid hygroscopic deterioration, and the freeze-drying machine can effectively remove the water in it to ensure product quality and storage stability.
Veterinary drugs and veterinary drug intermediates
In the production and storage process also need to be dried, freeze-drying machine is the ideal choice.
Fine chemical products
Such as surfactants, catalysts, additives, etc., these products also need to be dried during production and storage to avoid hygroscopic deterioration.
Other areas
Animal collagen, enzyme, serum, strains and other biological products.
All kinds of flowers, ornamental plants and animals, specimens, cultural relics and other items that need to remain in their original state and extend the preservation time.
The application of new materials such as porous ceramics, catalysts, graphene, and ultrafine materials is also being explored.
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