10-150L Stainless Steel Bioreactor
Description
Technical Parameters
Product Introduction
Stainless Steel Bioreactor for Laboratory and Pilot-Scale Biological Processes
Achieve Chem stainless steel bioreactors are designed for controlled biological cultivation, laboratory research and pilot-scale process development applications.
With available vessel volumes from 10L to 150L, these bioreactor systems provide a controlled environment through precise monitoring and regulation of key process parameters, including temperature, agitation speed (rpm), pH, dissolved oxygen (DO), defoaming, feeding, air flow and pressure.
The bioreactor vessel is manufactured using 316L or 304 stainless steel materials and can be configured with automatic control functions and advanced monitoring options according to different biological process requirements.
Key Features of Stainless Steel Bioreactor
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1. 316L / 304 Stainless Steel Vessel Construction The stainless steel bioreactor adopts 316L or 304 stainless steel vessel materials to provide a reliable equipment solution for biological cultivation processes. Different stainless steel material options are available according to specific process requirements.
2.Flexible 10L-150L Volume Range Achieve Chem stainless steel bioreactors are available in multiple volume configurations to meet different laboratory and pilot-scale applications. Available total volumes include: 10L 15L 20L 30L 50L 100L 150L The working volume can be adjusted within approximately 30%-70% of the total vessel volume depending on process requirements. 3. Top-Driven Mechanical Stirring System The stainless steel bioreactor is equipped with a top-driven stirring system through mechanical coupling. This configuration provides stable agitation performance for maintaining uniform cultivation conditions during biological processes. The bioreactor supports in-situ steam disinfection, helping simplify sterilization procedures and maintain a controlled cultivation environment.
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Stainless Steel Bioreactor Standard Configuration
| Item | Description |
|---|---|
| Vessel Material | 316L / 304 Stainless Steel |
| Total Volume | 10L, 15L, 20L, 30L, 50L, 100L, 150L |
| Working Volume | 30%-70% of total volume |
| Stirrer | Top driven by mechanical coupling |
| Sterilization | In-situ steam disinfection |
| Control Parameters | Temperature, rpm, pH, DO, defoaming, feeding, air flow, pressure |
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Design and Functionality of Modern Biological Fermenters
A biological fermenter is a specialized piece of equipment designed to support the growth and metabolism of microbial, animal, or plant cells under controlled conditions. These conditions include optimal temperature, pH, dissolved oxygen levels, and nutrient supply. The design of a biological fermenter typically incorporates several key components:
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◆ Fermentation Chamber: This is the main compartment where the biological process occurs. It is usually made of stainless steel to ensure durability and sterility. ◆ Agitation System: To ensure uniform mixing and aeration within the fermentation chamber, agitators such as impellers or stirrers are employed. These help in maintaining homogeneous conditions throughout the fermentation process. ◆ Aeration System: The provision of oxygen is crucial for aerobic organisms. This is achieved through spargers or air diffusers that introduce sterile air into the fermentation broth. ◆ Cooling System: Temperature control is maintained using jackets or coils filled with a coolant. This prevents overheating and ensures optimal growth conditions. ◆ pH Control System: The pH of the fermentation broth is monitored and adjusted using acids, bases, or buffers to maintain the desired range. ◆ Nutrient Feed System: A controlled supply of nutrients, such as sugars, amino acids, vitamins, and minerals, is provided to sustain cell growth and metabolism. |
Types of Biological Fermenters
Biological fermenters can be classified based on various criteria, including the type of cells being cultured, the mode of operation, and the scale of production. Below are some of the most common types:
◆ Microbial Fermenters: These reactors are designed for the cultivation of microorganisms, such as bacteria, fungi, and yeast. Microbial fermentation is widely used in the production of antibiotics, enzymes, organic acids, and biofuels.
◆ Animal Cell Fermenters: Animal cell culture is more complex than microbial fermentation due to the higher nutritional and environmental requirements of animal cells. These reactors are used in the production of therapeutic proteins, vaccines, and monoclonal antibodies.
◆ Plant Cell Fermenters: Plant cell culture offers an alternative to traditional agricultural methods for the production of plant-derived compounds. Plant cell fermenters are used in the production of secondary metabolites, such as flavonoids and alkaloids, which have medicinal and industrial applications.
◆ Disposable Bioreactors: Disposable bioreactors are single-use systems that eliminate the need for cleaning and sterilization between batches. They are becoming increasingly popular due to their cost-effectiveness, ease of use, and reduced risk of contamination.
Automatic Configuration Options
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Advanced Automatic Control for Bioreactor OperationFor applications requiring higher automation levels, Achieve Chem stainless steel bioreactors can be configured with optional automatic control functions.
Available automatic configurations include:
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Advanced Configuration Options
Enhanced Monitoring and Process Control Functions
For advanced biological process requirements, additional monitoring and control functions can be integrated into the stainless steel bioreactor system.
Available options include:
Liquid level control
Tank weighing
Feed weighing system
Multi-channel feeding
Exhaust O₂ and CO₂ analysis
Bacteria quantity detection (viable cells or OD)
Methanol and ethanol detection
Online glucose and lactic acid detection
These configurations allow the bioreactor system to support more detailed process monitoring and control requirements.
Customized Stainless Steel Bioreactor Solutions
Designed According to Different Process Requirements
Achieve Chem provides customized stainless steel bioreactor solutions based on different biological process requirements.
Customization options include:
Vessel volume selection
Stainless steel material selection
Control configuration
Automatic operation functions
Advanced monitoring systems
Our bioreactor systems can be configured according to specific cultivation and process development requirements.
Applications of Stainless Steel Bioreactor
The field of biological fermenters is constantly evolving, with advancements in technology and engineering driving improvements in productivity, efficiency, and sustainability. Below are some of the key trends and developments in this field:
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Laboratory and Pilot-Scale Biological ApplicationsThe 10-150L stainless steel bioreactor is suitable for: Biological research Laboratory-scale cultivation Pilot-scale process development Biological cultivation process optimization Microbial and cell culture related applications |
Why Choose Achieve Chem Stainless Steel Bioreactor
Professional Customized Equipment Solutions
Achieve Chem focuses on providing customized chemical and biological equipment solutions.
The stainless steel bioreactor series combines flexible volume selection, configurable control systems and optional advanced monitoring functions to meet different laboratory and pilot-scale biological process requirements.
FAQ
Q: What volume range is available for the stainless steel bioreactor?
A: Achieve Chem stainless steel bioreactors are available from 10L to 150L, including 10L, 15L, 20L, 30L, 50L, 100L and 150L volume options.
Q: What materials are available for the bioreactor vessel?
A: The vessel can be manufactured using 316L stainless steel or 304 stainless steel according to process requirements.
Q: What is the working volume range of the bioreactor?
A: The working volume is approximately 30%-70% of the total vessel volume.
Q: What parameters can be monitored and controlled?
A: The stainless steel bioreactor can be configured for monitoring and control of temperature, rpm, pH, DO, defoaming, feeding, air flow and pressure.
Q: Does the bioreactor support automatic sterilization?
A: Yes. Optional automatic configuration includes one-touch automatic sterilization and automatic detection and control functions for air flow and tank pressure.
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