Hand Crank Tablet Press
ACHIEVE Supply two kinds of Rotary Tablet Press Machine
(1)Standard & GMP Qualified
Max. Pressure: 40KN-100KN
Max. Capacity (PC/H): 6,500-155,000
Machine Weight: 850Kg-2,100kg
(2)Economic Speicification
Max. Pressure: 10KN-50KN
Max. Capacity (PC/H): 9,000-15,000
Machine Weight: 200Kg-580kg
2. Customization:
(1)Design support
(2)Die customization
3. Assurance:
(1)CE and ISO certification Registered
(2)Trademark: ACHIEVE CHEM(since 2008)
(3)Replacement parts within 1-year for free
Description
Technical Parameters
A Hand Crank Tablet Press is a small,portable pharmaceutical device primarily used to make tablets or tablets in a laboratory or small-scale production environment.The device provides power by manually rotating a handle(the hand part),which drives the internal mechanical structure to complete the pressing process of the tablet.
Hand crank tablet press is suitable for laboratory trial production,teaching and small-scale production of various tablets,sugar tablets,calcium tablets and so on.Due to its small size,light weight,easy to carry and simple operation characteristics,it is also widely used in food,chemical and other industries of granular or powdered materials pressing.
The main part of the hand press is usually a gantry type body,which is welded from carbon steel. Its main components include spindle,deflector wheel,filling CAM,rocker arm,handle,lifting rod,feeder and die. Among them,the main shaft is connected with a core wheel and a filling CAM,and the right end of the shaft is equipped with a rocker arm and a handle,which are used to manually drive the main shaft,so as to drive the core wheel,filling CAM,lifting rod and feeder to work.
We provide Hand Crank Tablet Press, please refer to the following website for detailed specifications and product information.
Product: https://www.achievechem.com/tablet-press-machines/manual-tablet-punching-machine.html
Principles
| ► The specific work process 1) Preparation work Grind the material to be pressed,such as powder,to the appropriate fineness and prepare the mold. Install the mold on the hand press and ensure that it is firmly fixed. 2) Pressing process Rotate the handle,drive the main shaft and core wheel and other components to operate. Driven by the spindle,the filling CAM fills the raw material into the die hole of the mold. As the handle continues to rotate,the upper pressure wheel gradually descends,applying pressure to the material in the die hole. Under the action of pressure,the raw material is gradually compressed and formed into a tablet. 3) Film release and cleaning After the pressing is completed,the upper pressure wheel rises,the mold opens,and the tablet is removed from the die hole. Remove the tablets and carry out the necessary cleaning work,such as cleaning the mold,removing excess raw materials,etc. |
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► Key components and their functions Used to provide rotary power to drive the spindle and internal mechanical structure. A key component that connects the handle to the internal mechanical structure and transmits rotating power. Through the eccentric movement,drive the filling CAM and other parts to fill and press the raw materials. Control the filling amount of raw material to ensure that the amount of raw material in each die hole is consistent. Pressure is applied to the raw material in the die hole to compress and form it. Consisting of two upper and lower parts,used to hold the raw material and form the shape of the tablet. |
Core Component
Handle and drive system:
Handle: It is the part directly operated by the user and generates power by rotating the handle.
Transmission system: converts the rotating motion of the handle into the linear or rotating motion required inside the tablet press.This usually involves a series of gears,links,crankshafts and other mechanical parts that work together to ensure that power is delivered smoothly and accurately to the press mechanism.
Hand crank tablet press mechanism:
Upper and lower die(die): The core component of the press mechanism,usually made of cemented carbide or other wear-resistant materials.The upper die and the lower die are fixed in different parts of the device,and when the handle is rotated,they will move relative to each other to complete the pressing of the tablet.
Pressure device: connected with the transmission system,responsible for pushing the upper mold downward movement,closing with the lower mold,and applying pressure to the powder placed in the mold.The pressurization device should be designed to ensure that the pressure is evenly distributed to produce tablets of consistent quality.
Base and support:
Base: Provides stable support for the entire tablet press,ensuring that the machine does not shake or move during operation.The base is usually made of a strong material to withstand the forces generated by the tablet press while it is working.
Bracket: Used to support and hold the pressing mechanism and other critical components.The design of the bracket should ensure that the relative position between the components is accurate to ensure the normal operation of the tablet press.
Regulating mechanism:
Used to adjust the spacing between the upper and lower molds,pressure and other parameters to adapt to different specifications and materials of powder pressing needs.The adjusting mechanism usually includes parts such as knobs and dials, through which the user can accurately control the operating parameters of the tablet press.
Discharge mechanism(optional):
In some advanced models of hand-operated tablet presses,an automatic discharge mechanism may be equipped.When the tablet is pressed,the agency automatically pushes or separates the tablet from the mold for easy collection and disposal by the user. However, in the basic model of the hand-operated tablet press,the user may need to complete the unloading operation manually.
Bioavailability studies
Application Of Hand Crank Tablet Press In Bioavailability Study
► Preparation of experimental tablets
The manual tablet press can be used for in vivo and in vitro experiments in bioavailability research by mixing drug powder and auxiliary materials evenly and pressing them into tablets.
Tablets of different thickness,hardness and weight can be prepared by adjusting the pressure and filling amount of the tablet press to meet the needs of the experiment.
► Optimized formulation
In the study of bioavailability,the optimization of formulation is the key to improve the bioavailability of drugs.
The hand-rolled tablet press can easily prepare tablets with different prescription compositions,which can be used to compare the effects of different prescriptions on drug bioavailability.
By screening and optimizing the prescription,the solubility and dissolution rate of the drug can be improved,thus improving the bioavailability of the drug.
► In vitro and in vivo correlation studies
Tablets prepared by hand compression can be used for in vivo and in vitro correlation studies,that is,to compare the consistency of results in vivo and in vitro.
By establishing in vivo and in vitro correlation model,the absorption of drugs in vivo can be predicted,which provides important basis for drug research and development.
Considerations For Bioavailability Studies Using Hand Crank Tablet Press
► Preparation process control
When preparing tablets,parameters such as the quality of raw materials,mixing uniformity,tablet pressure and filling amount should be strictly controlled to ensure the stable and reliable quality of the prepared tablets.
At the same time,attention should be paid to avoid contamination and cross-contamination to ensure the accuracy of the experimental results.
► Experimental design
In the study of bioavailability,the experimental scheme should be reasonably designed,including the selection of experimental animals,the route and dose of administration,the sampling time and method.
Consistency of experimental conditions should be ensured in order to compare results under different experimental conditions.
► Data analysis
After the collection of experimental data,appropriate statistical methods should be used for analysis to compare the differences in bioavailability of different preparations.
At the same time,attention should be paid to the reliability and repeatability of experimental data to ensure the accuracy of experimental results.
How to optimize formulation
First of all,it is necessary to clarify the objective of optimizing the formulation,such as improving the solubility,dissolution rate and bioavailability of the drug,or improving the taste and stability of the drug.These goals will guide subsequent prescription optimization efforts.
Select and optimize the main drug
Determine the type and dosage of the main drug
According to the needs of drug development, select the appropriate type and dosage of the main drug.The active composition,purity,stability and other characteristics of the main drug are very important to the quality of the preparation.
Consider the physical properties of the main drug
Physical properties such as the particle size, crystal type and solubility of the main drug will affect the preparation and performance of the preparation.By adjusting these properties, formulation can be optimized.
Screening and optimization of excipients
Select the appropriate excipients
Excipients play a variety of roles in the preparation,such as forming,increasing stability, adjusting pH,etc.According to the nature of the main drug and the optimization goal,the appropriate type and dosage of excipients were selected.
Optimize the proportion of excipients
By changing the proportion of excipients,the hardness,brittleness,dissolution rate and other properties of the preparation can be adjusted. Tablets with different proportion of excipients were prepared by hand pressing mechanism,and performance tests were carried out to find the best proportion of excipients.
Adjust preparation process
Optimized granulation process
Granulation is an important part of the preparation process.By adjusting the parameters of the granulation process,such as the choice of adhesive,granulation temperature and time,the particle size and uniformity can be optimized,thus improving the quality of the preparation.
Adjusting the tablet process
Using the hand press to adjust the parameters of the tablet process,such as tablet pressure,filling amount,etc.,can prepare tablets with different thickness,hardness and weight.By comparing the properties of tablets prepared under different process conditions,the best tablet pressing process can be found.
In vitro and in vivo experiments were carried out to verify
In vivo experiments
The optimized formulation will be tested on animals to evaluate its bioavailability, pharmacodynamics and pharmacokinetics.The optimization effect can be verified by comparing the experimental results of different formulations in vivo.
In vitro experiment
In vitro dissolution,stability and other experiments were carried out to evaluate the quality of the preparation.By comparing the results of in vitro experiments of different preparations,the optimization effect can be further verified,and the reference can be provided for the follow-up research and development work.
Matters needing attention
Strict control of the preparation process
When preparing tablets,the quality of raw materials,mixing uniformity,tablet pressure and filling amount should be strictly controlled to ensure that the quality of the prepared tablets is stable and reliable.
Attention to the reliability and repeatability of experimental data
When conducting in vivo and in vitro experiments, the consistency of experimental conditions should be ensured,and attention should be paid to the reliability and repeatability of experimental data in order to compare the performance differences of different preparations.
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