Large Pharmaceutical Freeze Dryer
(a)10 series
Lab Scales Desktop(Freeze-dried material 1.5-2KG)
(b)12 series
Lab Scales Vertical(Freeze-dried material 2KG)
(c)18 series
Scientific Research Scales(Freeze-dried material 3KG)
2.Pilot Freeze Dryer:
0.2m²/0.3m²/0.5m²/1m²/2m²/---Pilot Scales(Freeze-dried material 3KG-20KG)
3.Industrial Freeze Dryer:
5㎡/10㎡/20㎡/30㎡/50㎡/100㎡/200㎡/300㎡(Freeze-dried Weight 5T~60T)
4.Customization: set up the specifications you need
(a)Freeze-dried Area
(b)Freeze-dried Weight
(c)Freeze-dried Material
(d)Interlayer Quantity/Size
(e)Cold Trap Temperature
Description
Technical Parameters
In the modern pharmaceutical industry, freeze-drying technology is widely used due to its unique advantages. The importance of large pharmaceutical freeze dryer as the core equipment in this field is self-evident. By adopting advanced control systems, such as PLC control systems or touch screen control systems, precise control of temperature, vacuum degree, time and other parameters can be achieved, thereby optimizing the drying effect. They are equipped with high-performance refrigeration and heating systems that can quickly reach and maintain the required low-temperature environment, ensuring that drugs are not damaged during the drying process.
As one of the important equipment in the pharmaceutical industry, large drug freeze dryers play a key role in ensuring drug quality, improving production efficiency, and promoting drug innovation. With the progress of science and technology and the continuous development of the pharmaceutical industry, large pharmaceutical freeze dryers will continue to develop in the direction of intelligence, automation, energy saving and environmental protection, multi-functional and customized.
Widely used in various fields of the pharmaceutical industry, such as biopharmaceuticals, vaccines, blood products, chemical drugs, etc. In these fields, equipment can effectively maintain the activity and stability of materials, improve the quality and safety of drugs. It also has advantages such as energy conservation, environmental protection, automation, and intelligence, which can improve production efficiency, reduce energy consumption, and reduce manual intervention.
We provide large pharmaceutical freeze dryer, please refer to the following website for detailed specifications and product information.
Product: https://www.achievechem.com/freeze-dryer/large-pharmaceutical-freeze-dryer.html
Specifications Table
Freeze Drying Process
The working principle of a large pharmaceutical freeze dryer is based on the three state changes of water. Firstly, freeze the dried item below the triple point in a low-temperature environment, so that the moisture in the item changes from liquid to solid (ice). Then, under vacuum conditions, the solid water (ice) is directly sublimated into water vapor by heating, thereby being removed from the item and achieving the purpose of drying. Throughout the process, the vacuum system establishes low-pressure conditions for the sublimation drying chamber, the heating system provides sublimation latent heat to the material, and the refrigeration system provides the required cooling capacity to the cold trap and drying chamber.
performance parameter
Capacity and size
Large pharmaceutical freeze-drying machines typically have a larger capacity to meet the needs of large-scale production. The drying chamber capacity may range from tens to hundreds of liters, and the freeze-drying area is correspondingly large to meet the production needs of different scales.
Temperature range and accuracy
The equipment has a wide temperature range and can adapt to the drying needs of different substances. The minimum temperature can usually reach -80 ℃ or lower to meet the drying requirements for low-temperature sensitive substances. At the same time, the equipment has an accurate temperature control system to ensure the accuracy and stability of temperature during the drying process.
Vacuum degree and vacuum pump
Large pharmaceutical freeze-drying machines are usually equipped with high-performance vacuum pumps to establish low-pressure conditions and promote water sublimation. The vacuum degree can usually reach a higher level, such as 15PA or lower, to improve drying efficiency.
Heating power and method
The equipment has sufficient heating power to meet the heat demand during the drying process. Common heating methods include electric heating and steam heating to ensure sufficient heat is provided during the drying process.
Control system
Large pharmaceutical freeze-drying machines are usually equipped with advanced control systems, such as PLC control systems or touch screen control systems. These systems have the characteristics of easy operation, rich functionality, and stable performance, which can achieve precise control of the drying process.
Operational principle
◆ The amount of water vapor in compressed air is determined by the temperature of the compressed air: while keeping the compressed air pressure basically unchanged, reducing the temperature of the compressed air can reduce the water vapor content in the compressed air, and excess water vapor will condense into liquid. A freeze dryer uses this principle to dry compressed air using refrigeration technology. Therefore, the refrigerated dryer has a refrigeration system. Front view of the principle of Gree freeze-drying machine.
◆ The refrigeration system of a freeze dryer belongs to compression refrigeration, consisting of four basic components: a refrigeration compressor, a condenser, an evaporator, and an expansion valve. They are connected by pipelines to form a closed system, where the refrigerant continuously circulates and changes state, exchanging heat with compressed air and cooling media.
◆ The refrigeration compressor sucks the low-pressure (low-temperature) refrigerant inside the evaporator into the compressor cylinder, and the refrigerant vapor is compressed, causing both pressure and temperature to increase simultaneously; High pressure and high temperature refrigerant vapor is compressed into the condenser, where the higher temperature refrigerant vapor exchanges heat with cooler water or air. The heat of the refrigerant is carried away by water or air and condensed, resulting in the refrigerant vapor becoming a liquid. This part of the liquid is then transported to the expansion valve, which restrains it into a low-temperature and low-pressure liquid and enters the evaporator; The low-temperature and low-pressure refrigerant liquid in the evaporator absorbs the heat of compressed air and vaporizes (commonly known as "evaporation"), while the compressed air condenses a large amount of liquid water after being cooled; The refrigerant vapor in the evaporator is then sucked away by the compressor, which completes a cycle of compression, condensation, throttling, and evaporation in the system.
◆ In the refrigeration system of a freeze-drying machine, the evaporator is a device for conveying cold energy, in which the refrigerant absorbs the heat of compressed air to achieve the purpose of dehydration and drying. The compressor is the heart, playing the role of inhaling, compressing, and delivering refrigerant vapor. A condenser is a device that releases heat, transferring the heat absorbed in the evaporator along with the heat converted from the input power of the compressor to the cooling medium (such as water or air) for removal. The expansion valve/throttle valve has a throttling and pressure reducing effect on the refrigerant, while controlling and regulating the amount of refrigerant liquid flowing into the evaporator, and dividing the system into two main parts: the high-pressure side and the low-pressure side.
Structural characteristics
Large pharmaceutical freeze dryer typically use stainless steel materials to ensure equipment corrosion resistance and hygiene standards. Its structural characteristics mainly include the following aspects:
Intelligent control
The device is equipped with an intelligent control system that can automatically manage the entire freeze-drying process, ensuring ideal vacuum pressure and drying temperature, thereby maintaining the freshness and activity of materials.
Large capacity design
The equipment has a large tray space and can handle large amounts of materials simultaneously, improving production efficiency.
Efficient refrigeration
Advanced refrigeration technology is adopted to ensure that the equipment reaches the required low-temperature environment in a short period of time.
Energy conservation and environmental protection
The equipment fully considers energy-saving and environmental protection factors in the design and manufacturing process, adopts energy-saving materials and technologies, and reduces energy consumption and emissions.
Check the shut-off valve and pressure gauge
Check stop valve
Visual inspection
Ensure that all stop valves (such as compressor suction and exhaust valves, liquid supply valves, hand valves, etc.) are properly opened or closed.
Observe valve body for cracks, leaks, or signs of corrosion.
Operation check
Manually operate each stop valve to ensure smooth opening and closing.
Check that the stem and handle are secure and not loose or damaged.
Reading check
For a globe valve with a reading gauge, check that the reading is normal and compare it with the specifications in the equipment operating manual.
Check the pressure gauge
Calibration check:
Before using the pressure gauge, make sure it has been calibrated and is within its validity period. Calibration can be handed over to a professional instrument testing organization.
Reading check:
Observe the pointer position of the pressure gauge to ensure that the indicated pressure value is within the normal range specified in the equipment operating manual.
Note whether the pressure gauge has abnormal fluctuations or the pointer is stuck.
Appearance inspection:
Check that the dial of the pressure gauge is clear and free of scratches or dirt.
Make sure the connection of the pressure gauge is not loose or leaking.
System pressure corresponding check:
Based on the rated pressure of the dryer pressure gauge system, check whether the gauge pointer is within the normal range.
If the indicator is too low or too high, you need to further check whether the device has faults, such as the compressor output pressure, oil pressure regulating valve setting, and refrigerant type.
Precautions
Safety first: Before performing any inspection, make sure the device is turned off and in a safe condition.
Professional guidance: For those who are not familiar with the operation of the equipment, inspection should be carried out under the guidance of professional personnel.
Record and report: Record check results in device maintenance logs to track device running status and detect potential problems in a timely manner.
Check electrical system
Power check
Voltage and current measurement
Use a voltmeter and ammeter to measure the input voltage and current of the equipment and ensure that they conform to the range specified in the equipment operating manual.
If the voltage or current is abnormal, check the power supply line and the power supply device.
Power supply stability check
Observe the fluctuation of the power supply voltage and current to ensure that they fluctuate within the allowable range.
If the power supply is unstable, you may need to install a voltage regulator or take other measures to improve the quality of the power supply.
Electrical component inspection
Fuse and circuit breaker inspection
Check that fuses and circuit breakers are intact and that there are no signs of blowouts or trips.
If a blown fuse or circuit breaker trip is found, the cause should be identified and the damaged component replaced.
Relay and contactor checks
Observe relay and contactor contacts for wear or ablation.
Check the coils of relays and contactors for heat or abnormalities.
If contact wear or abnormal coil is found, it should be replaced or repaired in time.
Terminal check
Check whether the wiring terminals are loose or corroded.
Make sure all wiring is secure and reliable, with no signs of falling off or short-circuiting.
Control system inspection
1) Temperature controller and pressure controller check:
Observe whether the displayed values of the temperature controller and pressure controller are consistent with the actual situation.
Check whether the set value of the controller is correct and adjust it as required.
If the controller is found to display abnormal or set incorrect values, the cause should be identified and repaired or replaced.
2) Programmable Logic Controller (PLC) check:
If the equipment is equipped with a PLC, it should be checked that its operating status and procedures are correct.
Ensure that the input and output signals of the PLC are normal, without misoperation or failure.
Safety device inspection
1) Scram button and alarm device check:
Check whether the emergency stop button is in good condition and can trigger shutdown normally.
Test whether the alarm device is capable of sounding an alarm under abnormal conditions.
2) Grounding device check:
Ensure that the grounding device is securely grounded.
Other notes
1) Use professional tools:
When checking the electrical system, professional electrical testing tools should be used, such as multimeters, oscilloscopes, etc.
2) Follow safety specifications:
Before conducting an electrical system inspection, ensure that the equipment is turned off and disconnected from the power supply.
During the inspection process, the relevant electrical safety regulations should be observed to avoid dangerous situations such as electric shock or short circuit.
3) Records and reports:
Record the check results in device maintenance logs to track the device running status and detect potential problems in a timely manner.
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