100L Rotovap

100L Rotovap is Achieve Chem's large-capacity rotary evaporator, purpose-built for the distillation and concentration of liquid mixtures at industrial and pilot-production scale. As the largest model in Achieve Chem's rotovap lineup, it increases surface area by rotating the mixture within the flask while a vacuum pump removes evaporated solvent - enabling fast, efficient separation and purification of compounds at volumes far beyond standard lab-scale units.

What sets the 100L model apart from Achieve Chem's smaller-capacity rotary evaporators (10L, 20L, 30L, 50L) isn't just size - it's the engineering required to safely and efficiently operate at this scale: a dual receiving flask system for uninterrupted collection, an explosion-proof motor option for hazardous solvent environments, and a hydraulic lift system to handle a 100L flask that would otherwise be too heavy and hot to move by hand.

*If your process requires a smaller capacity, see Achieve Chem's [10 Liter Rotovap] or [50 Liter Rotovap] for dedicated specifications at those scales.*

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Condenser

Vertical tri-effect condensing tube design, offering a large condensing area and high solvent recovery efficiency suited to the higher evaporation rates of the 100L model.

Explosion proof Motor and controller:

• Electrical, rotary control, heating control, wiring, and safety protection can all be upgraded to explosion-proof specifications, up to **EXDIIVT4** rating - an important safety consideration when processing large volumes of flammable solvents.

Receiving Flask:

• Two receiving flasks (50L + 20L) with an independent two-vacuum-valve design allow rapid pressure relief and product discharge without affecting the overall system vacuum - critical for maintaining continuous operation at large batch volumes.

Electric Lift Water/Oil Bath:

SS304 stainless steel heating bath with a bottom discharge valve for easy operation. Includes a sample testing port built into the rotating flask for convenient in-process sampling, and an optional hot shield to prevent scalding during bath heating.

Hydraulic lift:

A hot 100L rotary flask is difficult and hazardous to remove manually. The hydraulic lift raises and positions the rotating flask, making flask removal and handling significantly safer and more convenient at this scale.

Interested in a 100L rotovap with similar capabilities for your lab? [Send inquiry now] 

The specification of 100L Rotovap

RE-100LEx Full Specifications

Parameter	Value
Rotary flask	100L
Collect flask	50L + 20L
Condensing Area	1.5m²
Evaporating Rate	H₂O ≥15L/h, Alcohol ≥31.5L/h
Discharge valve	PTFE (Teflon) Bottom Discharge Valve
Motor power	750W
Rotation speed	0–60 r/min
Bath power	18KW
Voltage	380V, 50/60Hz, 3-phase
Bath temp. range	Water: RT–100°C; Oil: RT–180°C, ±0.2°C
Glass material	GG-17 (3.3) High Borosilicate Glass
PTFE Sealing	Standard
Vacuum Meter	Standard
Vacuum rate	<133Pa (1.33mbar, 1Torr, 1mmHg)
Bath dimension	930×930×950mm
Machine size	1800×1000×2600mm

 

Other Capacities in the Rotovap Series

Model	Rotary Flask	Evaporating Rate (H₂O)	Full Specifications
RE-10LEx	10L	>3L/h	View 10 Liter Rotovap page
RE-20LEx	20L	>5L/h	Contact us for full datasheet
RE-30LEx	30L	>7L/h	Contact us for full datasheet
RE-50LEx	50L	>9L/h	View 50 Liter Rotovap page

 

Interested in a rotovap with similar capabilities for your lab? [Send email now]

 

Operation Steps

The following are the basic operating steps for distillation and concentration of mixtures using 100L Rotovap: ● Prepare equipment: Check if the equipment is installed correctly, ensuring that all components are securely installed and sealed properly. Turn on the vacuum pump and connect the cooling water pipeline. ● Sample preparation: Prepare the mixture to be processed, accurately weigh the sample, and add it to the feed bottle. Add any necessary auxiliary agents such as bases, acids, catalysts, etc. to the mixture. ● Start distillation: Insert the feed bottle into the rotary evaporator and close the feed bottle and upper pressure control valve. Start the rotary evaporator and adjust the angle and speed of the barrel to mix with the sample, then turn on the vacuum pump to form a certain negative pressure. ● Adjust the vacuum degree as needed: Adjust the vacuum degree by changing the working efficiency of the vacuum pump or adjusting the valve on the vacuum gauge as needed. If necessary, liquid nitrogen or cooling water can be added to control the temperature. ● Collect products: When the mixture begins to boil, collect the generated steam using a collection bottle. Control the collection speed by adjusting the height of the bottle. After the evaporation process is completed, turn off the vacuum pump and stop rotating the evaporator. ● Cleaning equipment: Clean the interior of the equipment thoroughly for the next experiment.

 

Rotovap vs. Sublimator

There are some differences in the working principle and application between 100L Rotovap and other distillation equipment (such as sublimators). The following are the main differences between them:

● Chemical wastewater treatment: rotary evaporator can be used in chemical wastewater treatment plant for wastewater evaporation and concentration process, reduce the volume of wastewater discharged, reduce the cost of treatment.

● Chemical pharmaceutical: in chemical pharmaceutical plant, rotary evaporator can be used for drug solution evaporation and concentration and crystallization process, improve drug purity and yield.

● Fine chemical: in the fine chemical plant, rotary evaporator can be used for a variety of fine chemicals evaporation, concentration, crystallization and separation process, to meet the needs of fine chemical production.

It should be noted that the specific factory application cases may be different due to production process, raw material characteristics, product requirements and other factors. Therefore, in the actual application, need to choose the appropriate rotary evaporator model and operating parameters according to the specific circumstances.

Overall, it's mainly used for distillation and concentration of liquid mixtures, while sublimators are mainly used for the sublimation process of solid mixtures or substances. There are significant differences in their working principles, application fields, device structures, and operational complexity, and suitable equipment needs to be selected according to specific needs.

Given its large processing capacity, the 100L Rotovap is best suited to applications that require handling substantial liquid volumes in a single batch:

 *For a broader overview of rotary evaporator applications across chemicals, pharmaceuticals, environmental analysis, fragrance, and polymer materials, see Achieve Chem's [Rotary Evaporators] overview page.*

► Concentration and purification of biological products

The 100L Rotovap is also applied in biological fields where large-volume, temperature-sensitive processing is required - including the concentration and purification of biological products such as enzymes, proteins, peptides, antibodies, and vaccines, biological sample processing (e.g., DNA, RNA, or protein extraction), and solvent evaporation in biological experiments. Because the unit evaporates under reduced pressure, it lowers the required evaporation temperature, helping protect the activity of temperature-sensitive biological materials while its higher evaporation capacity supports faster processing of larger sample batches than smaller rotovap models.

Interested in a rotovap with similar capabilities for your lab? [Send inquiry now]

The 100L Rotovap is the right choice when your process has outgrown smaller-capacity rotary evaporators - specifically when you need continuous large-batch solvent recovery, dual-flask collection without interrupting vacuum, or safer handling of a heavy, hot flask via hydraulic lift. For chemical, pharmaceutical, and fine chemical operations scaling from pilot testing to production-level throughput, these 100L-specific engineering features (dual receiving flask, explosion-proof upgrade option, hydraulic lift) are the deciding factors, not just the flask size itself.

If your batch volumes are smaller, Achieve Chem's [10 Liter Rotovap] and [50 Liter Rotovap] may be a more cost-effective fit - our team can help you determine the right capacity based on your actual throughput needs.

Interested in a rotovap with similar capabilities for your lab? [Speak to an Engineer]

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