50l Rotovap
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50l Rotovap

1. Specification:
(1)1L/2L---Manual lifting with irony base/Manual lifting with SS base/Electric lifting
(2)3L/5L/10L/20L/30L/50L---Manual Lifting/Electric Lifting
***Price List for whole above, inquire us to get
2. Customization:
(1)Design support
(2)Directly supply the Senior R&D organic intermediate, shorten your R&D time and cost
(3)Share the advanced purifying technology with you
(4)Supply the high quality chemicals and analysis reagent
(5)We want to assist you on Chemical Engineering (Auto CAD, Aspen plus etc.)
3. Assurance:
(1)CE and ISO certification Registered
(2)Trademark: ACHIEVE CHEM(since 2008)
(3)Replacement parts within 1-year for free
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Description

Technical Parameters

The 50L rotovap, also known as the 50L rotary evaporator, is a large laboratory equipment used for efficient evaporation and solvent recovery. Compared to small rotary evaporators, its size and capacity make it suitable for handling large amounts of liquids. The main components include boiling bottles, condensers, collection bottles, and rotating motors. These components are typically installed in sturdy frames or brackets to ensure stability and safety during operation. Other accessories such as vacuum pumps, coolers, and control panels may also be equipped. Vacuum pumps are used to create a low-pressure environment within the system, which helps with the evaporation process. Coolers help maintain a controlled temperature inside the condenser to maximize condensation efficiency. The control panel provides an interface to monitor and adjust various parameters, such as temperature, vacuum degree, and rotation speed.

 

Rotary Evaporators | Shaanxi Achieve chem-tech

 

We provide xxx, please refer to the following website for detailed specifications and product information.

Product: https://www.achievechem.com/chemical-equipment/rotary-evaporators.html

 

Product Introduction

 

Structure-of-Rotary-Evaporator | Shaanxi Achieve chem-tech

Structure-of-Rotary-Evaporator | Shaanxi Achieve chem-tech

The above picture shows a highly specialized 50L rotovap whose core functions are reflected through its fine structure and diverse components. This is clearly an advanced rotary evaporator system. Facility, as an indispensable experimental tool in fields such as chemistry, biochemistry, pharmaceuticals, and materials science, is mainly used for continuous distillation of solutions under reduced pressure conditions, thereby efficiently separating and purifying solvents or solutes. Below, I will provide a detailed introduction to the various components, working principles, and application scenarios of this facility.

 

Product Application in Chemical Experiments

In drug research, it is often necessary to purify and purify drugs to improve their purity and activity. For example, researchers developing novel drugs may use a 50L facilityto concentrate and purify intermediate or final products during drug synthesis.

 

50l Rotovap Applications | Shaanxi Achieve chem-tech

 

Solvent Recovery

 

 

The use of solvents is very common in chemical experiments. However, the waste of solvents not only increases the cost of experiments, but also may cause pollution to the environment.50L facility can effectively recover solvents and realize the reuse of resources.

For example, in the process of removing a large amount of ethanol from cannabis oil, researchers can use the 50L facility to separate the ethanol from the mixture by controlling the evaporation temperature and vacuum, realizing the recovery of solvents.

 

Natural product extraction

 

 

Natural products such as plant extracts are usually large in volume and low in concentration, and need to be concentrated and purified to obtain the active ingredients.50L facility can effectively concentrate natural products and extract their active ingredients through purification.

Take the extraction of rutin as an example, researchers can use ethanol to soak acacia rice, get the leaching solution, and then evaporate the solvents such as ethanol through the 50L facility to get the rutin extract.

 

Receiving solution distillation during chromatographic separation

 

 

During chromatographic separations, the receiving solution usually contains target compounds and impurities. In order to get pure target compounds, it is necessary to distill the receiving solution. 50L facility can continuously distill a large number of volatile solvents under reduced pressure to realize the concentration and purification of the receiving solution.

 

Efficient and stable performance

 

 

The 50L facility is equipped with excellent heat conduction performance and precise control system, which can rapidly transfer the heat source to the liquid to be treated and realize rapid evaporation. Meanwhile, by precisely controlling the heating temperature and rotating speed, users can easily adjust the evaporation rate to meet different experiments and production needs.

 

To sum up, 50L rotovap is widely used in chemical experiments, which not only improves the experimental efficiency, but also reduces the experimental cost and realizes the saving of resources and the protection of environment.

 

Applications in Biological Experiments
Drying of biological samples

 

In biological experiments, it is often necessary to dry biological samples such as cells, microorganisms, tissues, etc. for preservation and analysis.

Biological sample drying is a crucial process in preserving specimens for research, analysis, and storage. It involves removing moisture from tissues, cells, or other biological materials to prevent degradation, microbial growth, and maintain structural integrity. Techniques such as freeze-drying (lyophilization), air-drying, and critical point drying are commonly used. Freeze-drying, for instance, involves freezing the sample and then subliming the ice directly into vapor under vacuum, minimizing structural damage. Air-drying is simpler but may cause shrinkage or deformation. Critical point drying uses liquid carbon dioxide to replace water in the sample, which is then removed at the critical point of carbon dioxide, preserving fine details. Proper drying ensures samples retain their original properties, enabling accurate scientific studies.

  • Operation process: Add the biological sample solution into the evaporation bottle of the facility, and realize the drying of biological samples by evaporating the water in the solution through heating, rotating and condensing operations.
  • Advantages: 50L facility is characterized by fast concentration and easy operation, which can efficiently dry biological samples while maintaining their structure and activity.

 

Solvent recovery in biological experiments

 

Solvent recovery in biological experiments is a crucial process aimed at reducing waste, conserving resources, and minimizing environmental impact. It involves collecting and purifying solvents used in various laboratory procedures, such as extractions, reactions, and chromatography. Techniques like distillation, evaporation, and adsorption are employed to separate and concentrate the solvents. Distillation, for instance, utilizes heat to vaporize the solvent, which is then condensed back into a liquid form, removing impurities. Evaporation methods expose the solvent to controlled conditions to promote gradual evaporation, followed by condensation. Adsorption utilizes specific materials to bind and separate solvents from mixtures. Proper solvent recovery not only adheres to environmental regulations but also promotes sustainable laboratory practices.

  • Application background: In biological experiments, it is often necessary to use various organic solvents for extraction, dissolution and other operations. In order to save costs and protect the environment, these solvents need to be recovered.
  • Operation process: The used solvents are recovered through the evaporation and condensation function of 50L rotovap. The specific operation steps include adding the solvent into the evaporation bottle, making it evaporate by heating, then condensing the vapor into liquid by condenser, and finally collecting the recovered solvent.
  • Features: 50L facility can maintain high vacuum during the solvent recovery process to ensure the purity and recovery rate of solvent.

 

Specific applications in drug synthesis and purification

50L rotovap | Shaanxi achieve chem

● Solvent removal for drug synthesis reactions
In drug synthesis, the reaction system often needs to be carried out in a specific solvent, and the solvent needs to be removed after the reaction is completed to obtain the target product. Rotary evaporator can remove the solvent quickly under low temperature and low pressure, avoiding the side reaction triggered by high temperature. Example:

Peptide synthesis: After removing the reaction solvent by rotary evaporator, the next condensation reaction can be carried out directly to improve the synthesis efficiency.
Total synthesis of natural products: in the synthesis of complex natural products, rotary evaporator is used to remove reaction solvents and by-products to improve product purity.
● Purification of drug intermediates
After the synthesis of drug intermediates often contain unreacted raw materials, by-products and solvent residues, need to improve the purity through purification. Rotary evaporator combined with crystallisation, recrystallisation or chromatographic separation technology, can be highly efficient purification of intermediates. For example:

Chiral intermediates purification: through the rotary evaporator concentration of chiral intermediates reaction solution, combined with chiral chromatographic separation, to obtain high optical purity of the intermediates.
Purification of metal complex intermediates: in the synthesis of metal complexes, rotary evaporator is used to remove the reaction solvent, combined with recrystallisation technology to improve the purity and stability of the complexes.

● Extraction and concentration of active ingredients
In plant medicine, microbial fermentation liquid and other natural resources, the extraction and concentration of active ingredients is an important part of drug research and development. Rotary evaporator can effectively retain the biological activity of active ingredients through low temperature concentration technology. Example:

Extraction of active ingredients in traditional Chinese medicine: removing solvents such as ethanol from traditional Chinese medicine extracts to obtain high concentrations of active ingredients, such as flavonoids and alkaloids.
Concentration of antibiotics in fermentation broth: In the treatment of antibiotic fermentation broth, rotary evaporator is used to remove water and organic solvents to increase the concentration of antibiotics for subsequent purification.
● Solvent recovery and recycling
Drug synthesis often use a large number of organic solvents, rotary evaporator can efficiently recover solvents, reduce production costs and reduce environmental pollution. For example:

Recovery of dichloromethane, ethyl acetate and other solvents: through the rotary evaporator recovery reaction solvents, can be reused after simple treatment, reduce raw material consumption.
Recovery of solvents for supercritical fluid extraction: In supercritical fluid extraction technology, rotary evaporator is used to recover supercritical fluid and improve the economy of the process.

50L rotovap | Shaanxi achieve chem

Application Cases

Case 1: Purification of anti-cancer drug intermediates
In the synthesis of an anti-cancer drug intermediate, the reaction solution contains unreacted raw materials and by-products. After removing the reaction solvent by rotary evaporator, combined with column chromatography separation technology, the intermediate with purity >98% was obtained, laying the foundation for subsequent drug synthesis.
Case 2: Extraction of active ingredients of traditional Chinese medicine
The ethanol solvent was removed from the extract of Astragalus, and the extract was concentrated to 1/10 of the original volume by rotary evaporator, which significantly increased the content of Astragalus polysaccharide, and provided high-purity raw materials for the research and development of drug preparations.

 

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